L R Ranganath Selected Research

nitisinone (Orfadin)

6/2022	Temporal adaptations in the phenylalanine/tyrosine pathway and related factors during nitisinone-induced tyrosinaemia in alkaptonuria.
3/2022	Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria.
12/2021	Treatment of osteoporotic fractures in alkaptonuria by teriparatide stimulates bone formation and decreases fracture rate - A report of two cases.
1/2021	Evaluating the aortic stenosis phenotype before and after the effect of homogentisic acid lowering therapy: Analysis of a large cohort of eighty-one alkaptonuria patients.
6/2020	Fatal acute haemolysis and methaemoglobinaemia in a man with renal failure and Alkaptonuria - Is nitisinone the solution?
11/2019	Quantification of the flux of tyrosine pathway metabolites during nitisinone treatment of Alkaptonuria.
9/2019	Interference of hydroxyphenylpyruvic acid, hydroxyphenyllactic acid and tyrosine on routine serum and urine clinical chemistry assays; implications for biochemical monitoring of patients with alkaptonuria treated with nitisinone.
5/2019	Correction to: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
1/2019	Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.
10/2018	Data on items of AKUSSI in Alkaptonuria collected over three years from the United Kingdom National Alkaptonuria Centre and the impact of nitisinone.

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L R Ranganath Research Topics

Disease

25	Alkaptonuria 06/2022 - 02/2010
4	Body Weight (Weight, Body) 06/2022 - 01/2001
4	Osteoporosis 12/2021 - 03/2007
4	Obesity 05/2013 - 01/2001
3	Ochronosis 01/2021 - 01/2018
3	Inflammation (Inflammations) 01/2018 - 05/2013
2	Weight Gain 06/2022 - 04/2008
2	Inborn Genetic Diseases (Disease, Hereditary) 10/2018 - 12/2011
2	Disease Progression 01/2018 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 05/2013 - 08/2009
1	Osteoporotic Fractures 12/2021
1	Aortic Valve Stenosis (Aortic Stenosis) 01/2021
1	Hemolysis 06/2020
1	Renal Insufficiency (Renal Failure) 06/2020
1	Tyrosinemias (Tyrosinemia) 09/2019
1	Alkaptonuric ochronosis 01/2018
1	Insulin Resistance 05/2013
1	Calculi (Calculus) 02/2010
1	Cardiovascular Diseases (Cardiovascular Disease) 11/2009
1	Bone Resorption 09/2009
1	Hyperhomocysteinemia 12/2007
1	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 01/2001
1	Vascular Diseases (Vascular Disease) 01/2001

Drug/Important Bio-Agent (IBA)

16	nitisinone (Orfadin)FDA Link 06/2022 - 01/2015
11	Tyrosine (L-Tyrosine)FDA Link 06/2022 - 12/2011
10	Homogentisic AcidIBA 01/2021 - 02/2010
3	PolymersIBA 10/2018 - 02/2010
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 09/2009
3	EnzymesIBA 03/2016 - 02/2010
2	Proteins (Proteins, Gene)FDA Link 06/2022 - 05/2014
2	Urea (Carbamide)FDA LinkGeneric 06/2022 - 11/2019
2	Neurotransmitter Agents (Neurotransmitter)IBA 05/2019 - 01/2019
2	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 03/2016 - 02/2010
2	Hormones (Hormone)IBA 05/2013 - 01/2001
2	Peptides (Polypeptides)IBA 05/2013 - 11/2009
2	HomocysteineIBA 12/2007 - 01/2001
2	Sulfhydryl Compounds (Thiols)IBA 12/2007 - 01/2001
1	CreatinineIBA 06/2022
1	Phenylalanine (L-Phenylalanine)FDA Link 06/2022
1	Diphosphonates (Bisphosphonates)IBA 12/2021
1	Teriparatide (Parathar)FDA Link 12/2021
1	SolutionsIBA 06/2020
1	4-hydroxyphenyllactic acidIBA 09/2019
1	AcidsIBA 09/2019
1	Amino Acids FDA Link 01/2018
1	5-hydroxyindoleIBA 01/2018
1	Acetic Acid (Vinegar)FDA LinkGeneric 01/2018
1	catch-relaxing peptide (Mytilus)IBA 01/2015
1	Melanins (Melanin)IBA 01/2015
1	ImmunosorbentsIBA 01/2015
1	CollagenIBA 01/2015
1	Benzethonium (Magic, Formula)IBA 05/2014
1	Peroxidase (Myeloperoxidase)IBA 05/2014
1	Interleukin-6 (Interleukin 6)IBA 05/2013
1	Glucagon-Like Peptide 1 (GLP 1)IBA 05/2013
1	CalciumIBA 02/2010
1	SaltsIBA 02/2010
1	Biological ProductsIBA 11/2009
1	GhrelinIBA 11/2009
1	OsteoprotegerinIBA 09/2009
1	AdiponectinIBA 09/2009
1	Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA 08/2009
1	Glucose (Dextrose)FDA LinkGeneric 04/2008
1	Cysteine Proteases (Cysteine Protease)IBA 12/2007
1	Folic Acid (Vitamin M)FDA LinkGeneric 03/2007
1	AndrosteroneIBA 01/2001
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2001
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2001
1	CarbohydratesIBA 01/2001
1	Glutathione PeroxidaseIBA 01/2001
1	Methionine (L-Methionine)FDA Link 01/2001
1	VitaminsIBA 01/2001

Therapy/Procedure

6	Therapeutics 12/2021 - 09/2015
1	Protein-Restricted Diet (Diet, Protein Restricted) 06/2022
1	Slit Lamp 01/2018
1	Aftercare (After-Treatment) 01/2018